Cardiac/Diabetic Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF METFORMIN & VOGLIBOSE

Introduction

Metformin is an anti-diabetic or oral antihyperglycemic product which is used for type-II diabetic patients which are non-insulin dependent belongs to the class of products called Biguanides. Voglibose is an oral antihyperglycemic product which is an alpha-glucosidase inhibitor prescribed for a patient with diabetes mellitus for lowering post-prandial blood glucose level. 

Class Anti-diabetic or Antihyperglycemic

Mechanism of action

In type-II diabetes, insulin secretion from the pancreas is too little & liver releases glucose in excess, Metformin acts on the liver to slow the release of glucose & also slows the absorption of glucose from the intestine. Voglibose works as an inhibitor of alpha-glucosidase, an enzyme essential for the digestion of carbohydrates.

Pharmacokinetics

Bioavailability of Metformin-50-60%

Metabolism- Metformin-Not by hepatic metabolism or biliary excretion

Metabolism-Voglibose-By intestinal enzyme & microbial flora 

Excretion of Metformin- Unchanged in urine 

Excretion of Voglibose-Urine & feces 

Pharmacological Uses

Metformin & Voglibose combination may be prescribed for the treatment of Diabetes, Reduces blood glucose level thereby prevents Kidney damage, and Blindness, Nerve problems & Sexual function problems & Loss of limbs. Metformin may prevent the cardiovascular disease.

Side Effects

Diarrhea

Skin reactions

Hypoglycemia

Abdominal distention

Increased LFT

Hepatotoxicity

Abdominal distension

Skin rashes, urticaria 

product Interactions

Antidiabetic & Insulin (effect Increase)

Furosemide (alterations in a pharmacokinetic parameter of both) 

Glucocorticosteroids 

Loop diuretics 

Dosage-

One tablet twice or thrice a day with heavy meals. 

Consult with Doctor or Pharmacist. 

We are the supplier of Metformin & Voglibose & also a trader of Metformin & Voglibose.

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