Cardiac/Diabetic Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF RAMIPRIL & AMLODIPINE

Introduction


It is an effective combination of angiotensin-converting enzyme inhibitor & calcium channel blocker which are used for the prevention of cardiac disorder by reducing the blood pressure to maintain its flow. 

Class ACE inhibitors & Calcium channel blocker

Mechanism of Action

Ramipril action can be seen by its antagonizing action on the angiotensin-converting enzyme which reduces the breakdown of bradykinin. On the other hand, Amlodipine blocking action be observed on calcium ion influx, which leads to vasodilation to reduce the pressure. 

Pharmacokinetics

Absorption-Slowly but completely absorbed from GIT

Bioavailability of Ramipril-28%-44%

Bioavailability of Amlodipine-64-90%

Metabolism of Ramipril-Hepatic metabolism (75%)

Protein binding of Ramipril-73% 

Protein binding of Amlodipine-97.5%

A half-life of Ramipril-13-17 hours 

A half-life of Amlodipine-30-50 hours

Pharmacological Uses

The combination therapy of Ramipril & Amlodipine proving itself better as an antihypertensive than individuals. Their action is due to the ability to relax blood vessels. So it can be recommended in coronary artery disease, Heart-related chest pain, chronic stable angina, Vasospastic angina, Prevent Strokes.

Side Effects

Worsening chest pain

Palpitations 

Slow & irregular heartbeat

Loss of appetite or taste 

Numbness or fainting 

Bloody Diarrhea 

product Interaction

Etoricoxib & Heparin

Some of NSAID’s like Aceclofenac, Diclofenac 

Atenolol, Barbital & Atorvastatin

Alfuzosin, Amphetamine (increases hypotensive action)

Amphotericin B, Amorolfine (adverse effects)    

Dosage

For a dose recommendation, consult with your healthcare practitioner. 

We are the supplier of Ramipril & Amlodipine & also a trader of Ramipril & Amlodipine.


RAMIPRIL 5mg, AMLODIPINE BESYLATE 5mg Tablet Blister 10*10