PHARMA THIRD PARTY CONTRACT MANUFACTURER OF RAMIPRIL & AMLODIPINE
It is an effective combination of angiotensin-converting enzyme inhibitor & calcium channel blocker which are used for the prevention of cardiac disorder by reducing the blood pressure to maintain its flow.
Class ACE inhibitors & Calcium channel blocker
Mechanism of Action
Ramipril action can be seen by its antagonizing action on the angiotensin-converting enzyme which reduces the breakdown of bradykinin. On the other hand, Amlodipine blocking action be observed on calcium ion influx, which leads to vasodilation to reduce the pressure.
Absorption-Slowly but completely absorbed from GIT
Bioavailability of Ramipril-28%-44%
Bioavailability of Amlodipine-64-90%
Metabolism of Ramipril-Hepatic metabolism (75%)
Protein binding of Ramipril-73%
Protein binding of Amlodipine-97.5%
A half-life of Ramipril-13-17 hours
A half-life of Amlodipine-30-50 hours
The combination therapy of Ramipril & Amlodipine proving itself better as an antihypertensive than individuals. Their action is due to the ability to relax blood vessels. So it can be recommended in coronary artery disease, Heart-related chest pain, chronic stable angina, Vasospastic angina, Prevent Strokes.
Worsening chest pain
Slow & irregular heartbeat
Loss of appetite or taste
Numbness or fainting
Etoricoxib & Heparin
Some of NSAID’s like Aceclofenac, Diclofenac
Atenolol, Barbital & Atorvastatin
Alfuzosin, Amphetamine (increases hypotensive action)
Amphotericin B, Amorolfine (adverse effects)
For a dose recommendation, consult with your healthcare practitioner.
We are the supplier of Ramipril & Amlodipine & also a trader of Ramipril & Amlodipine.