PHARMA THIRD PARTY CONTRACT MANUFACTURER OF RABEPRAZOLE & DOMPERIDONE
Rabeprazole can be studied as an inhibitor of proton pump which is used for healing gastric problems like acidic stomach & gas. It is also used as the antiulcer compound. Domperidone can be studied as an inhibitor of Dopamine receptor which is used as an antiemetic compound, for the release of prolactin & increases the movement in the gastrointestinal tract.
Class Proton pump inhibitor & Dopamine receptor antagonist
Mechanism of action
Rabeprazole is an antisecretory compound which functions to suppress the amount of gastric acid by inhibiting the functioning of H+/K+-ATPase system which gets activated in acidic medium. Domperidone function is to promote gastric emptying by increasing lower esophageal sphincter pressure for GIT movement & to control vomiting. It antagonizes the action of dopamine receptor (D2 & D3) at gastric level & chemoreceptor trigger.
Absorption of combination-Rapid
Bioavailability of Rabeprazole - 52%
Bioavailability of Domperidone-15%
Metabolism of Rabeprazole-Hepatic
Protein binding of Rabeprazole-96.3%
Protein binding of Domperidone-91-93%
The half-life of Rabeprazole-1-2 hours
The half-life of Domperidone-7 hours
The combination of Rabeprazole & Domperidone is used for duodenal ulcer, Nausea & vomiting, Gastroesophageal reflux disease & stomach acid & gas & stomach ulcers.
Digoxin & Ketoconazole (pH-dependent interaction)
Chloramphenicol (decreases metabolism of Rabeprazole)
Aceclofenac, Acetaminophen (its metabolism decreases)
Caffeine (its metabolism decreases)
Amphetamine (its absorption increases)
Cimetidine (metabolism decreases)
Each capsule/tablet contains 20mg Rabeprazole of & 30mg of Domperidone/20mg Rabeprazole of & 10mg of Domperidone. The dose recommended is 1-2 capsules per day or as suggested by the healthcare professional.
We are the supplier of Rabeprazole & Domperidone & also a trader of Rabeprazole & Domperidone.
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