General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF DICLOFENAC POTASSIUM & PARACETAMOL 

Introduction

NSAIDs (Non-steroidal anti-inflammatory products) are the class which includes painkillers, analgesic, & antipyretic. Diclofenac is a NSAID & has anti-inflammatory & analgesic action & Paracetamol has analgesic & antipyretic effects. When it comes in combination, the effect of these products get enhanced & provides more relief from fever & pain. 

Class

Analgesic (Non-Opioid) & Antipyretic, Non-Steroidal Anti-Inflammatory products (NSAIDs).

Mechanism of Action

The Diclofenac works by inhibiting the cyclooxygenase enzyme (COX-2) which works as an important material/ingredient for the formation of prostaglandin which promotes to inflammation. In this mechanism of action, of this combination paracetamol will show its action first so that patient can get relief from pain & Diclofenac will show its effect after paracetamol.

Pharmacokinetics

Absorption-product absorbed completely 

Bioavailability of Diclofenac-50%

The onset of action of the product is 30-60 min 

Duration of action of the product is 6-12hrs

Plasma protein binding- Diclofenac- less than 99%

Plasma protein binding-Paracetamol-less than 20%

The half-life of Diclofenac-2 hours 

The half-life of Paracetamol-1-4 hours

Pharmacological Uses

Diclofenac potassium & paracetamol can be prescribed in Joint & muscular pain, Inflammation of the eye, Post-operative pain, Ankylosing spondylitis, Menstrual pain, Dental Pain, Sports injuries & Joint stiffness by arthritis.

Side Effects of Diclofenac potassium & paracetamol

GI Disturbances

Nephrotic Syndrome

Epigastric pain Bronchospasm

Prolonged bleeding time

Hepatic impairment

Cardiac failure

product Interaction

The product which can interrupt with the therapeutic action of Diclofenac potassium & paracetamol are 

Potentiates potassium-sparing diuretics

ACE inhibitors

Aliskiren

Angiotensin II receptor blockers

Corticosteroids 

Dosage

Each tablet contains diclofenac sodium 50 mg & paracetamol 500 mg, 

The Dose recommended is thrice a day or as directed by Doctor/pharmacist.

We are the supplier Diclofenac potassium & paracetamol & also a trader of Diclofenac potassium & paracetamol.

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