Antibiotics Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF CEFPODOXIME PROXETIL & OFLOXACIN

Introduction


This is the combination of greatly active antibiotics against bacterial infections only. Cefpodoxime Proxetil is a Cephalosporin third-generation antibiotic against gram Positive & negative bacteria. Ofloxacin is a representative of the group of antimicrobials & is a fluoroquinolone.

Class Third-Generation Cephalosporin & Fluoroquinolone antibiotic.

Antibacterial Spectrum 

The antibacterial spectrum of this combination is widened & extended against respiratory tract infection. Active against gram (+ve) & gram (-ve) bacteria.

Mechanism of action

The combination of Cefpodoxime Proxetil & Ofloxacin is counter to bacteria because of his killing nature. Cefpodoxime Proxetil is a proproduct which is then metabolized to Cefpodoxime which is an active form. It blocks the synthesis of the cell wall of bacteria. Ofloxacin inhibits the supercoiling activity of bacterial DNA Gyrase that is to inhibit the formation of the nucleic acid of bacteria, therefore, this combination puts the bacteria to death.

Pharmacokinetics

Bioavailability of Cefpodoxime-50%

Bioavailability of Ofloxacin-98%

Protein-binding- Cefpodoxime -20-30%

Half-Life of Cefpodoxime -2-3 hours (by dialysis)

A half-life of Ofloxacin-9 hours

Elimination- Cefpodoxime-29-33% in 12 hours (unchanged in urine)

Elimination -Ofloxacin-65-80% in 48 hours (unchanged via kidneys)

Pharmacological Uses 

Cefpodoxime & Ofloxacin can be prescribed in Upper & Lower Respiratory Tract Infection, Urinary Tract Infection, Skin & Soft Tissue Infection, Sexually transmitted infection, Asthma, Eye & ear infection, Typhoid, Pneumonia and Acute Bronchitis & Lung Abscess.

Side Effects of Cefpodoxime & Ofloxacin

Allergic reactions like rash

Hives or itching

Swelling of the face, lips & tongue

Confused, nervous

Anaphylactic shock & photosensitivity

Nephrotoxicity & Sinus tachycardia

product Interaction

product interact with Cefpodoxime & Ofloxacin are-

Antacids

Diuretics

Omeprazole

Probenecid

Nephrotoxic product

Dosage

8-10 mg/kg per day in a single or two doses. (100 mg, 200 mg, 400 mg).

We are the supplier of cefpodoxime & Ofloxacin & also a trader of cefpodoxime & Ofloxacin.

* The following symptoms are suggestive & needs to be confirmed before promoting or coating anywhere & anybody whom so ever. Power2pharma.com & its parent company NEWS pharma Pvt. Ltd. is not responsible for its authenticity.





 


CEFPODOXIME PROXETIL 200mg, OFLOXACIN 200mg Tablet ALU-ALU 10*10