PHARMA THIRD PARTY CONTRACT MANUFACTURER OF CEFPODOXIME PROXETIL & OFLOXACIN
This is the combination of greatly active antibiotics against bacterial infections only. Cefpodoxime Proxetil is a Cephalosporin third-generation antibiotic against gram Positive & negative bacteria. Ofloxacin is a representative of the group of antimicrobials & is a fluoroquinolone.
Class Third-Generation Cephalosporin & Fluoroquinolone antibiotic.
The antibacterial spectrum of this combination is widened & extended against respiratory tract infection. Active against gram (+ve) & gram (-ve) bacteria.
Mechanism of action
The combination of Cefpodoxime Proxetil & Ofloxacin is counter to bacteria because of his killing nature. Cefpodoxime Proxetil is a proproduct which is then metabolized to Cefpodoxime which is an active form. It blocks the synthesis of the cell wall of bacteria. Ofloxacin inhibits the supercoiling activity of bacterial DNA Gyrase that is to inhibit the formation of the nucleic acid of bacteria, therefore, this combination puts the bacteria to death.
Bioavailability of Cefpodoxime-50%
Bioavailability of Ofloxacin-98%
Protein-binding- Cefpodoxime -20-30%
Half-Life of Cefpodoxime -2-3 hours (by dialysis)
A half-life of Ofloxacin-9 hours
Elimination- Cefpodoxime-29-33% in 12 hours (unchanged in urine)
Elimination -Ofloxacin-65-80% in 48 hours (unchanged via kidneys)
Cefpodoxime & Ofloxacin can be prescribed in Upper & Lower Respiratory Tract Infection, Urinary Tract Infection, Skin & Soft Tissue Infection, Sexually transmitted infection, Asthma, Eye & ear infection, Typhoid, Pneumonia and Acute Bronchitis & Lung Abscess.
Side Effects of Cefpodoxime & Ofloxacin
Allergic reactions like rash
Hives or itching
Swelling of the face, lips & tongue
Anaphylactic shock & photosensitivity
Nephrotoxicity & Sinus tachycardia
product interact with Cefpodoxime & Ofloxacin are-
8-10 mg/kg per day in a single or two doses. (100 mg, 200 mg, 400 mg).
We are the supplier of cefpodoxime & Ofloxacin & also a trader of cefpodoxime & Ofloxacin.
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