PHARMA THIRD PARTY CONTRACT MANUFACTURER OF NIMESULIDE & PARACETAMOL
The combination of Nimesulide & Paracetamol is used for speedy relief from pain & fever. This is the combination of Non-steroidal anti-inflammatory, Analgesic & antipyretic properties of these two active products. Nimesulide is an NSAID & has equally analgesic action as that of paracetamol. So that on the basis of analgesic property & onset of action of product it comes in the market in Nimesulide & Paracetamol combination form.
Non-Steroidal Anti-Inflammatory (NSAIDs) & Analgesia
Mechanism of action
Nimesulide action is shown by inhibiting the action of cyclooxygenase enzyme which acts as a catalyst for the prostaglandin synthesis which causes swelling & pain at the site of injury & Paracetamol is a weak inhibitor of Prostaglandins biosynthesis. It also increases the pain threshold to increase the blood flow to the skin.
The onset of action of Nimesulide-30-60 minutes
The onset of action of Paracetamol-30-60 minutes
Duration of action of Nimesulide is 8-10 hours
Duration of action of Paracetamol-6 hours
The half-life of Nimesulide-2 days
The half-life of Paracetamol-1-4 hours
Pharmacological uses of Nimesulide & Paracetamol
Nimesulide & Paracetamol is used in Painful Inflammatory conditions, Back pain, Dysmenorrhea, Postoperative pain, Osteoarthritis, Fever, Tooth-ache, Sprains, Wounds, Headache, Cold, Acute & joint pain & Rheumatoid arthritis.
Side effects of Nimesulide & Paracetamol
Nimesulide & Paracetamol combination has some adverse effects which are
Increases hepatotoxic potential
Feeling of sickness
Increased sweating & Gastritis
Nimesulide & Paracetamol tablet may interact with-
Interfere with a laboratory test.
The usual dose is 100 mg twice a day
Children- 5mg/kg of body weight in 2 or 3 divided dose
We are the supplier of Nimesulide & Paracetamol & also a trader of Nimesulide & Paracetamol.
* The following symptoms are suggestive & needs to be confirmed before promoting or coating anywhere & anybody whom so ever. Power2pharma.com & its parent company NEWS pharma Pvt. Ltd. is not responsible for its authenticity.