General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF NIMESULIDE & PARACETAMOL

Introduction

The combination of Nimesulide & Paracetamol is used for speedy relief from pain & fever. This is the combination of Non-steroidal anti-inflammatory, Analgesic & antipyretic properties of these two active products. Nimesulide is an NSAID & has equally analgesic action as that of paracetamol. So that on the basis of analgesic property & onset of action of product it comes in the market in Nimesulide & Paracetamol combination form.

Class 

Non-Steroidal Anti-Inflammatory (NSAIDs) & Analgesia

Mechanism of action

Nimesulide action is shown by inhibiting the action of cyclooxygenase enzyme which acts as a catalyst for the prostaglandin synthesis which causes swelling & pain at the site of injury & Paracetamol is a weak inhibitor of Prostaglandins biosynthesis. It also increases the pain threshold to increase the blood flow to the skin. 

Pharmacokinetics 

The onset of action of Nimesulide-30-60 minutes

The onset of action of Paracetamol-30-60 minutes

Duration of action of Nimesulide is 8-10 hours 

Duration of action of Paracetamol-6 hours

The half-life of Nimesulide-2 days 

The half-life of Paracetamol-1-4 hours 

Pharmacological uses of Nimesulide & Paracetamol

Nimesulide & Paracetamol is used in Painful Inflammatory conditions, Back pain, Dysmenorrhea, Postoperative pain, Osteoarthritis, Fever, Tooth-ache, Sprains, Wounds, Headache, Cold, Acute & joint pain & Rheumatoid arthritis.

Side effects of Nimesulide & Paracetamol

Nimesulide & Paracetamol combination has some adverse effects which are 

Increases hepatotoxic potential

Feeling of sickness

Heartburn

Dizziness

Allergic reaction

Increased sweating & Gastritis 

product interaction 

Nimesulide & Paracetamol tablet may interact with-

Alcohol

Cyclosporine

Ketoconazole

Interfere with a laboratory test.

Dosage 

The usual dose is 100 mg twice a day

Children- 5mg/kg of body weight in 2 or 3 divided dose

We are the supplier of Nimesulide & Paracetamol & also a trader of Nimesulide & Paracetamol.

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