PHARMA THIRD PARTY CONTRACT MANUFACTURER OF NIMESULIDE, PARACETAMOL & SERRATIOPEPTIDASE
Nimesulide, Paracetamol & Serratiopeptidase combination is prepared for pain & fever management. Nimesulide is a Non-steroidal anti-inflammatory product (NSAID) also has Analgesic & Anti-pyretic action. Paracetamol (acetaminophen) derivative of acetanilide is an analgesic & Anti-pyretic effects. Serratiopeptidase is a proteolytic enzyme contribute to reducing pain & swelling.
Class NSAID, Analgesic & Anti-pyretic
Mechanism of action
Nimesulide works on the principal of NSAID’s that is inhibition of cyclooxygenase-2 for minimizing the prostaglandin synthesis. Paracetamol also decreases prostaglandin synthesis but is a weak inhibitor of COX-2. It increases pain threshold & inhibits the pain signal in the brain. Serratiopeptidase work to change the antigenicity by binding to alpha-2-macroglobulin in the blood which is transferred to the site of inflammation.
Absorption-Completely absorbed orally
The onset of action of Nimesulide-30-60 minutes
The onset of action of Paracetamol-30-60 minutes
The onset of action of Serratiopeptidase-30-60 minutes
Duration of action of Nimesulide is 8-10 hours
Duration of action of Paracetamol-6 hours
Duration of action of Serratiopeptidase-8-10 hours
The half-life of Nimesulide-2 days
The half-life of Paracetamol-1-4 hours
Arthritic pain, Dental pain, ENT condition, Sprains, Post-surgical pain, Inflammation in respiratory infection, Osteoarthritis, Fever, Tooth-ache, Acute & joint pain & Rheumatoid arthritis, Painful Inflammatory conditions, Back pain, Dysmenorrhea
Nausea, vomiting & Diarrhoea
The combination may interfere with
Antifungal, Ketoconazole-Hepatotoxic effect
The anti-tuberculosis product, isoniazid
Interactions between NSAID
The anticoagulant effect of Warfarin
Each tablet contains Nimesulide 100mg, Paracetamol 325mg & Serratiopeptidase 15mg & recommended dose is 1 tablet once/twice a day or as prescribed by the doctor.
We are the supplier of Nimesulide, Paracetamol & Serratiopeptidase & also a trader of Nimesulide, Paracetamol & Serratiopeptidase.
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