General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF NIMESULIDE, PARACETAMOL & SERRATIOPEPTIDASE

Introduction


Nimesulide, Paracetamol & Serratiopeptidase combination is prepared for pain & fever management. Nimesulide is a Non-steroidal anti-inflammatory product (NSAID) also has Analgesic & Anti-pyretic action. Paracetamol (acetaminophen) derivative of acetanilide is an analgesic & Anti-pyretic effects. Serratiopeptidase is a proteolytic enzyme contribute to reducing pain & swelling.

Class NSAID, Analgesic & Anti-pyretic

Mechanism of action

Nimesulide works on the principal of NSAID’s that is inhibition of cyclooxygenase-2 for minimizing the prostaglandin synthesis. Paracetamol also decreases prostaglandin synthesis but is a weak inhibitor of COX-2. It increases pain threshold & inhibits the pain signal in the brain. Serratiopeptidase work to change the antigenicity by binding to alpha-2-macroglobulin in the blood which is transferred to the site of inflammation. 

Pharmacokinetics 

Absorption-Completely absorbed orally

The onset of action of Nimesulide-30-60 minutes

The onset of action of Paracetamol-30-60 minutes

The onset of action of Serratiopeptidase-30-60 minutes

Duration of action of Nimesulide is 8-10 hours 

Duration of action of Paracetamol-6 hours

Duration of action of Serratiopeptidase-8-10 hours 

The half-life of Nimesulide-2 days 

The half-life of Paracetamol-1-4 hours 

Pharmacological uses

Arthritic pain, Dental pain, ENT condition, Sprains, Post-surgical pain, Inflammation in respiratory infection, Osteoarthritis, Fever, Tooth-ache, Acute & joint pain & Rheumatoid arthritis, Painful Inflammatory conditions, Back pain, Dysmenorrhea

Side effects

Epigastric discomfort

Nausea, vomiting & Diarrhoea

Heartburn

Abdominal cramps 

Renal failure

Hypersensitivity reaction 

Pruritus 

product interaction 

The combination may interfere with 

Antifungal, Ketoconazole-Hepatotoxic effect

The anti-tuberculosis product, isoniazid

Amoxicillin/clavulanic acid 

Interactions between NSAID 

The anticoagulant effect of Warfarin 

Dosage

Each tablet contains Nimesulide 100mg, Paracetamol 325mg & Serratiopeptidase 15mg & recommended dose is 1 tablet once/twice a day or as prescribed by the doctor. 

We are the supplier of Nimesulide, Paracetamol & Serratiopeptidase & also a trader of Nimesulide, Paracetamol & Serratiopeptidase.

* The following symptoms are suggestive & needs to be confirmed before promoting or coating anywhere & anybody whom so ever. Power2pharma.com & its parent company NEWS pharma Pvt. Ltd. is not responsible for its authenticity.


NIMESULIDE 100mg, PARACETAMOL 325mg, SERRATIOPEPTIDASE 10mg Tablet ALU-ALU 10*10