PHARMA THIRD PARTY CONTRACT MANUFACTURER OF METHYLPREDNISOLONE
Methylprednisolone is an Anti-inflammatory corticosteroid has similarities with the hormone produced by the adrenal gland. Methyl Prednisolone Sodium Succinate is the sodium succinate ester of Methyl Prednisolone. It is a synthetic Glucocorticoid with minimal mineralocorticoid activity.
Mechanism of action
Glucocorticoids modify the body’s immune responses to diverse stimuli, transcription & protein synthesis & then at the site of inflammation they inhibit leukocyte infiltration. Methyl Prednisolone is a potent anti-inflammatory steroid with greater anti-inflammatory potency than prednisolone. It works to treat people with low levels of Corticosteroids by replacing steroids. It also reduces swelling & redness by changing the way of working of the immune system.
The intravenous injection of methylprednisolone sodium succinate demonstrable effects is evident within one hour & persists for a variable period.
Bioavailability of Methylprednisolone-80-99%
Protein binding of Methylprednisolone-78%
The half-life of Methylprednisolone—3 hours
Excretion of the administered dose-within 12 hours
Methylprednisolone is useful in Control of severe or incapacitating allergic conditions, Treatment of Asthma, Atopic dermatitis, Contact Dermatitis, product Hyper Sensitivity Reactions, Perennial or Seasonal Allergic rhinitis, Serum Sickness, Transfusion Reactions, Herpetiformis, Mycosis Fungoides, Ulcerative Colitis acquired (autoimmune) Hemolytic Anemia, Congenital Hypoplastic Anemia (Diamond- Black fan Anemia), Idiopathic Thrombocytopenic purpura in adults, Tuberculosis Meningitis, Leukemias & Lymphomas, Ocular Inflammatory Conditions, To induce diuresis, Rheumatoid Arthritis & Ankylosing spondylitis.
Elevation of Blood Pressure
Salt & Water retention
Increased Excretion of Potassium
Increase Calcium Excretion
Amphotericin B injection & Potassium-depleting agent
Hepatic Enzyme Inhibitors (Ketoconazole)
Aceclofenac & Acetylsalicylic acid
Bismuth subcitrate or subnitrate
Intramuscular- 0.03-0.2 mg/kg or 1-6.25 mg/m2 IM 1-2 times daily
30 mg/kg administered intravenously over at least 30 minutes.
We are the supplier of Methylprednisolone Sodium Succinate & also a trader of Methylprednisolone Sodium Succinate.
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