Cardiac/Diabetic Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF METFORMIN, GLIMEPIRIDE & PIOGLITAZONE

Introduction


This is the combination of three oral antihyperglycemic products, Metformin, Glimepiride & Pioglitazone useful for the management of Non-insulin diabetes mellitus. Metformin refers to the class of products called Biguanides which shows antidiabetic action. Glimepiride a long-acting product refers to the class of sulfonylureas for lowering blood glucose. Pioglitazone is a part of Thiazolidinedione class used to treat diabetes (type-2)

Class Biguanides & sulfonylureas & Thiazolidinedione

Mechanism of action

In type-II diabetes, insulin secretion from the pancreas is too little & liver releases glucose in excess, Metformin acts on the liver to slow the release of glucose. Glimepiride stimulates the release of insulin by binding to ATP-sensitive potassium channel receptor which stimulates calcium ion concentration to induce insulin secretion. Pioglitazone works to activate Peroxisome Proliferator-Activated Receptor Gamma (PRAR) to increase the transcription of insulin-responsive genes used for controlling production & utilization of insulin. 

Pharmacokinetics

Bioavailability of Metformin 50-60%

Absorption of Glimepiride-completely absorbed (100%)

Absorption of Pioglitazone-well absorbed 

Protein binding of Glimepiride-99.5%

Protein binding of Pioglitazone-99%

Half-life in plasma of Metformin-6.2 hours

Half-life in plasma of Glimepiride-5 hours 

Half-life in plasma of Pioglitazone-3-7 hours & 16-24 hours 

Pharmacological Uses

Metformin, Glimepiride & Pioglitazone combination may be prescribed for the management of Diabetes (Type-2), Reduces blood glucose level thereby prevents Kidney damage, and Blindness, Nerve problems & Sexual function problems & Loss of limbs. Metformin may prevent the cardiovascular disease.

Side Effects

Fluid retention

Edema

Cholestatic jaundice

Allergic skin reaction

Photosensitivity reaction 

Hemolytic anemia

Vomiting, metallic taste & diarrhea 

product Interactions

Beta-blockers

Phenytoin

Rifampin

Methylprednisolone

Sympathomimetic products 

Dosage

We are the supplier of Metformin, Glimepiride & Pioglitazone & also a trader of Metformin, Glimepiride & Pioglitazone.

* The following symptoms are suggestive & needs to be confirmed before promoting or coating anywhere & anybody whom so ever. Power2pharma.com & its parent company NEWS pharma Pvt. Ltd. is not responsible for its authenticity.





 


PIOGLITAZONE 15mg, METFORMIN 500mg, GLIMEPIRIDE 2mg Tablet ALU-ALU 10*10