PHARMA THIRD PARTY CONTRACT MANUFACTURER OF METFORMIN, GLIMEPIRIDE & PIOGLITAZONE
This is the combination of three oral antihyperglycemic products, Metformin, Glimepiride & Pioglitazone useful for the management of Non-insulin diabetes mellitus. Metformin refers to the class of products called Biguanides which shows antidiabetic action. Glimepiride a long-acting product refers to the class of sulfonylureas for lowering blood glucose. Pioglitazone is a part of Thiazolidinedione class used to treat diabetes (type-2)
Class Biguanides & sulfonylureas & Thiazolidinedione
Mechanism of action
In type-II diabetes, insulin secretion from the pancreas is too little & liver releases glucose in excess, Metformin acts on the liver to slow the release of glucose. Glimepiride stimulates the release of insulin by binding to ATP-sensitive potassium channel receptor which stimulates calcium ion concentration to induce insulin secretion. Pioglitazone works to activate Peroxisome Proliferator-Activated Receptor Gamma (PRAR) to increase the transcription of insulin-responsive genes used for controlling production & utilization of insulin.
Bioavailability of Metformin 50-60%
Absorption of Glimepiride-completely absorbed (100%)
Absorption of Pioglitazone-well absorbed
Protein binding of Glimepiride-99.5%
Protein binding of Pioglitazone-99%
Half-life in plasma of Metformin-6.2 hours
Half-life in plasma of Glimepiride-5 hours
Half-life in plasma of Pioglitazone-3-7 hours & 16-24 hours
Metformin, Glimepiride & Pioglitazone combination may be prescribed for the management of Diabetes (Type-2), Reduces blood glucose level thereby prevents Kidney damage, and Blindness, Nerve problems & Sexual function problems & Loss of limbs. Metformin may prevent the cardiovascular disease.
Allergic skin reaction
Vomiting, metallic taste & diarrhea
We are the supplier of Metformin, Glimepiride & Pioglitazone & also a trader of Metformin, Glimepiride & Pioglitazone.
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