General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF MEFENAMIC ACID & DROTAVERINE HCL

Introduction


Mefenamic acid is a member of NSAID's (Non-steroidal anti-inflammatory) which possess anti-inflammatory with analgesic action used against swelling & pain in the body. Drotaverine is classified as antispasmodic product similar to papaverine.

Class-NSAID's & Antispasmodic 

Mechanism of action

Mefenamic acid works on the principal of NSAID’s that is it inhibits the action of cyclooxygenase enzyme which catalysis the prostaglandin (responsible for pain & inflammation) synthesis. Drotaverine HCl inhibits phosphodiesterase enzyme IV which decreases cyclic AMP & calcium ions as a result of which blood vessel get dilate against spasm.

Pharmacokinetics

Absorption-Rapidly or well absorbed 

The onset of action- Mefenamic acid-1-2 hours

The onset of action-Drotaverine-30 minutes

Duration of action-Mefenamic acid-6 hours

Duration of action Drotaverine-4 hours

Protein binding of Mefenamic acid-90%

Protein binding of Drotaverine-80-95%

The Half-life- Mefenamic acid -2-4 hours

The half-life of Drotaverine-7-12 hours 

Pharmacological Uses

Mefenamic acid & Drotaverine combination can be prescribed in Dysmenorrhea, Post-surgical uterine spasm, Gastrointestinal colic, Renal colic, biliary colic, Uterine irritability, Pain associated with IUCD insertion, PID or HSG, Heavy bleeding during periods, fever, migraine headache.

Side Effects

Constipation 

Nausea & sweating 

Flushing 

Irregular heart rhythm

Sleep disorders 

Abdominal pain

Anorexia, pyrosis

product Interactions

The products which can interfere with the action of Mefenamic acid & Drotaverine are 

Anti-muscarinic

Levodopa

Benzodiazepines 

Other NSAIDs

Dosage

One tablet is taken every 6-8 hours or consults with your doctor or pharmacist (healthcare professional). 

We are the supplier of Mefenamic acid & Drotaverine HCL & also a trader of Mefenamic acid & Drotaverine HCL.

* The following symptoms are suggestive & needs to be confirmed before promoting or coating anywhere & anybody whom so ever. Power2pharma.com & its parent company NEWS pharma Pvt. Ltd. is not responsible for its authenticity.





 


DROTAVERINE HCL 80mg, MEFENAMIC ACID 250mg Tablet ALU-ALU 10*10