Cardiac/Diabetic Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF METFORMIN & GLICLAZIDE

Introduction

Metformin & Gliclazide is the combination of two oral antihyperglycemic products which is used to cure Type-2 diabetes (Non-insulin dependent diabetes mellitus). Metformin belongs to the Biguanides class & Gliclazide belongs to the sulfonylurea class. 

Class- Antidiabetic

Mechanism of Action

Gliclazide & Metformin acts ac reducing the blood sugar level that is glucose released from the liver (which increases in diabetes) & this combination stimulates the secretion of insulin from the pancreatic beta cells & Inhibits Platelet Aggregation.

Pharmacokinetics

Absorption of Metformin -absorbed from GI tract

Bioavailability of Metformin-50-60%

Duration of action- approx. 12 hours 

Protein-Binding of Metformin-negligible bound to plasma protein 

Protein-Binding of Gliclazide: 94%

Elimination- 10-12 hours 

A half-life of Metformin-6.2 hours  

A half-life of Gliclazide-10.4 hours 

Pharmacological Uses

The combination of these two Antidiabetic products are used in the treatment of type-2 diabetes (Non-insulin dependent), Control blood sugar level which prevents Kidney damage, Blindness, Nerve problems & Sexual function problems & Loss of limbs.

Side Effects

GI Disturbances

Skin Reaction, Leucopenia

Thrombocytopenia 

Agranulocytosis

Haemolytic Anaemia

Cholestatic Jaundice

Vomiting, Diarrhoea, Gastritis

Increased Transaminases

product Interactions

The combination may interact with 

Alcohol (causes nausea & flushing)

Salicylates, Phenylbutazone, Clofibrate, Sulphonamides, Oral Anticoagulants and MAOIs (increase the effect)

Rifampicin, Barbiturates, Alcohol, Diuretics, Diazoxide, Corticosteroids, Β-Blockers, Oestrogens (decrease the effect)

Dosage

As recommended by your Doctor or pharmacist.

We are the supplier of Metformin & GLICLAZIDE also a trader of Metformin & GLICLAZIDE.

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