General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF ETORICOXIB & THIOCOLCHICOSIDE

Introduction

This is the combination of NSAID & muscle relaxant where Etoricoxib plays the role of a non-steroidal anti-inflammatory product with analgesic, antipyretic & antiarthritic action & Thiocolchicoside plays a major role in relaxing the muscles. 

Class NSAID & Muscle Relaxant

Mechanism of action

Etoricoxib inhibits the action of COX-2 (cyclooxygenase enzyme) which reduces the prostaglandins (PGs) (responsible for the inflammation & pain at the injury’s site) synthesis from arachidonic acid. Thiocolchicoside works as an antagonist of GABA-A receptor by binding to it & strychnine-sensitive glycine receptors resulting in the reduction of 

Pharmacokinetics

Bioavailability of Etoricoxib- 100%      

Bioavailability of Thiocolchicoside-25%

Protein binding of Etoricoxib-92%

Protein binding of Thiocolchicoside-12.8%

Metabolism of Etoricoxib-Hepatic

The half-life of Etoricoxib-20-26 hours 

The half-life of Thiocolchicoside-3.2-7 hours 

Excretion- In urine & feces 

Pharmacological Uses

Etoricoxib & Thiocolchicoside prescribed for the prevention of Muscle pain & swelling, Muscle stiffness in spinal, in muscles disease & nerve disease. It is indicated in the treatment of Rheumatoid arthritis, Gout, Osteoarthritis & Ankylosing spondylitis. 

Side Effects

Constipation & Diarrhea 

Dry mouth & taste disturbance 

Blurred vision & anxiety 

Hypertension

Muscle cramps 

Anaphylactic reaction 

Gastralgia 

Elevating weight & appetite 

Mouth ulcers 

product Interactions

The products which can interact with this combination are 

Lorpiprazole (therapeutic effects of Thiocolchicoside is increases) 

Annamycin (its excretion rate decreases)

Atenolol (its antihypertensive action decreases)

Caffeine (Etoricoxib metabolism decreases)

Clodronic acid, Clobetasone (adverse effects increases) 

Dosage

For a dose, recommendation consults with your doctor or pharmacist (healthcare professional) 

We are the supplier of Etoricoxib & Thiocolchicoside & also a trader of Etoricoxib & Thiocolchicoside.

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