PHARMA THIRD PARTY CONTRACT MANUFACTURER OF ETORICOXIB & THIOCOLCHICOSIDE
This is the combination of NSAID & muscle relaxant where Etoricoxib plays the role of a non-steroidal anti-inflammatory product with analgesic, antipyretic & antiarthritic action & Thiocolchicoside plays a major role in relaxing the muscles.
Class NSAID & Muscle Relaxant
Mechanism of action
Etoricoxib inhibits the action of COX-2 (cyclooxygenase enzyme) which reduces the prostaglandins (PGs) (responsible for the inflammation & pain at the injury’s site) synthesis from arachidonic acid. Thiocolchicoside works as an antagonist of GABA-A receptor by binding to it & strychnine-sensitive glycine receptors resulting in the reduction of
Bioavailability of Etoricoxib- 100%
Bioavailability of Thiocolchicoside-25%
Protein binding of Etoricoxib-92%
Protein binding of Thiocolchicoside-12.8%
Metabolism of Etoricoxib-Hepatic
The half-life of Etoricoxib-20-26 hours
The half-life of Thiocolchicoside-3.2-7 hours
Excretion- In urine & feces
Etoricoxib & Thiocolchicoside prescribed for the prevention of Muscle pain & swelling, Muscle stiffness in spinal, in muscles disease & nerve disease. It is indicated in the treatment of Rheumatoid arthritis, Gout, Osteoarthritis & Ankylosing spondylitis.
Constipation & Diarrhea
Dry mouth & taste disturbance
Blurred vision & anxiety
Elevating weight & appetite
The products which can interact with this combination are
Lorpiprazole (therapeutic effects of Thiocolchicoside is increases)
Annamycin (its excretion rate decreases)
Atenolol (its antihypertensive action decreases)
Caffeine (Etoricoxib metabolism decreases)
Clodronic acid, Clobetasone (adverse effects increases)
For a dose, recommendation consults with your doctor or pharmacist (healthcare professional)
We are the supplier of Etoricoxib & Thiocolchicoside & also a trader of Etoricoxib & Thiocolchicoside.
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