General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF OMEPRAZOLE & DOMPERIDONE

Introduction

This is an impressive & result oriented combination of a proton pump inhibitor & Dopamine receptor antagonist. Omeprazole act as a proton pump inhibitor for lower the amount of gastric acid secretion in the stomach & Domperidone acts as Dopamine receptor antagonist which increases the movement throughout digestive system to get relief from Nausea & vomiting. 

Class Proton pump inhibitor & Dopamine receptor antagonist

Mechanism of action

Omeprazole job is to block the H+/K+-ATPase system which is assumed as an acid pump in gastric mucosa to close the last step of production of acid in the stomach. The antiemetic effect of Domperidone can be studied as its blocking action on dopamine receptor (D2 & D3) at gastric level & chemoreceptor trigger (responsible to mediates nausea) & Domperidone also simplifies & promote gastric emptying by increasing lower esophageal sphincter pressure. 

Pharmacokinetics

Absorption of combination-Rapid 

Bioavailability of Omeprazole - 30-40%

Bioavailability of Domperidone-15%

Protein binding of Omeprazole-95%

Protein binding of Domperidone-91-93%

A half-life of Omeprazole -0.5-1 hour 

A half-life of Domperidone-7 hours 

Excretion-Urinary excretion 

Pharmacological Uses

The combination of Omeprazole & Domperidone is used for the prevention & treatment of Gastroesophageal disease (GERD), Heartburn & dyspepsia, abdominal pain, Intestinal & stomach ulcers, Gas & Bitter fluid in stomach, Nausea & vomiting. 

Side Effects

Dry mouth & skin rashes 

Urinary tract infection 

Pain in joint 

Breast pain & Headache

Exhaustion

Insomnia & Vertigo 

product Interactions

Cimetidine & Sodium carbonate (bioavailability decreases)

Diazepam, Phenytoin & warfarin (elimination decreases) 

Anticholinergic product (adverse effects increases) 

Ceritinib (serum concentration increases) 

Aceclofenac, Acetaminophen (its metabolism decreases)

Dosage

As per recommended by the healthcare professional. 

We are the supplier of Omeprazole & Domperidone & also a trader of Omeprazole & Domperidone.

* The following symptoms are suggestive & needs to be confirmed before promoting or coating anywhere & anybody whom so ever. Power2pharma.com & its parent company NEWS pharma Pvt. Ltd. is not responsible for its authenticity.