PHARMA THIRD PARTY CONTRACT MANUFACTURER OF OMEPRAZOLE & DOMPERIDONE
This is an impressive & result oriented combination of a proton pump inhibitor & Dopamine receptor antagonist. Omeprazole act as a proton pump inhibitor for lower the amount of gastric acid secretion in the stomach & Domperidone acts as Dopamine receptor antagonist which increases the movement throughout digestive system to get relief from Nausea & vomiting.
Class Proton pump inhibitor & Dopamine receptor antagonist
Mechanism of action
Omeprazole job is to block the H+/K+-ATPase system which is assumed as an acid pump in gastric mucosa to close the last step of production of acid in the stomach. The antiemetic effect of Domperidone can be studied as its blocking action on dopamine receptor (D2 & D3) at gastric level & chemoreceptor trigger (responsible to mediates nausea) & Domperidone also simplifies & promote gastric emptying by increasing lower esophageal sphincter pressure.
Absorption of combination-Rapid
Bioavailability of Omeprazole - 30-40%
Bioavailability of Domperidone-15%
Protein binding of Omeprazole-95%
Protein binding of Domperidone-91-93%
A half-life of Omeprazole -0.5-1 hour
A half-life of Domperidone-7 hours
The combination of Omeprazole & Domperidone is used for the prevention & treatment of Gastroesophageal disease (GERD), Heartburn & dyspepsia, abdominal pain, Intestinal & stomach ulcers, Gas & Bitter fluid in stomach, Nausea & vomiting.
Dry mouth & skin rashes
Urinary tract infection
Pain in joint
Breast pain & Headache
Insomnia & Vertigo
Cimetidine & Sodium carbonate (bioavailability decreases)
Diazepam, Phenytoin & warfarin (elimination decreases)
Anticholinergic product (adverse effects increases)
Ceritinib (serum concentration increases)
Aceclofenac, Acetaminophen (its metabolism decreases)
As per recommended by the healthcare professional.
We are the supplier of Omeprazole & Domperidone & also a trader of Omeprazole & Domperidone.
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