PHARMA THIRD PARTY CONTRACT MANUFACTURER OF DEXTROMETHORPHAN, CHLORPHENIRAMINE MALEATE, PHENYLEPHRINE & PARACETAMOL
Dextromethorphan is a member of class morphinan which possesses stimulant, dissociative & sedative activity. It is prescribed to suppressant the cough. Chlorpheniramine is an antihistaminic product. Phenylephrine is classified as an agonist of the Alpha-1-adrenergic receptor which plays a role as a decongestant as it decreases the blockage of the air passage. Paracetamol is an acetanilide derivative used for its analgesic (pain killing) or antipyretic (fever-reducing) activities.
Class Morphinan, Decongestant, Analgesic & Antipyretic
Mechanism of action
Dextromethorphan functions as an opioid product. It is an antagonist to the NMDA glutamatergic receptor & alpha3/beta4 nicotinic receptor to attack serotonin reuptake pump & an agonist to the opioid sigma 1 and sigma 2 receptors. Chlorpheniramine maleate binds to the H1-receptor to control the action of histamine. Phenylephrine works as an agonist at alpha-1- adrenergic receptor for constricting the blood vessels, therefore, work as a vasoconstrictor. The therapeutic action of Paracetamol as an analgesic can be seen by elevating the pain threshold & anti-pyretic effect by blocking the effects produced by endogenous pyrogen.
Absorption of combination-Rapidly (oral)
Bioavailability of Phenylephrine-38%
Protein binding of Paracetamol- 25%
Protein binding of Phenylephrine-95%
Protein binding of Chlorpheniramine-72%
The half-life of Dextromethorphan-3-6 hours
The half-life of Paracetamol -1-4 hours
The half-life of Phenylephrine-2.1-3.4 hours
The half-life of Chlorpheniramine-21-27 hours
Dextromethorphan, Phenylephrine & Paracetamol merger is prescribed for the treatment of a cough with fever & pain occurred by smoking, emphysema & asthma, stuffy nose, sinus pressure, sinus pain & problems associated with illness.
Nervousness and Wheezing
Allergic symptoms (rashes, hives)
Swelling of face, lips, tongue & throat
Tightness in chest
Yellow skin or eyes
For a dose, recommendation consults with your doctor or pharmacist (healthcare professional)
We are the supplier of Dextromethorphan, Phenylephrine & Paracetamol & also a trader of Dextromethorphan, Phenylephrine & Paracetamol.
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