General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF DEXTROMETHORPHAN, CHLORPHENIRAMINE MALEATE, PHENYLEPHRINE & PARACETAMOL

Introduction


Dextromethorphan is a member of class morphinan which possesses stimulant, dissociative & sedative activity. It is prescribed to suppressant the cough. Chlorpheniramine is an antihistaminic product. Phenylephrine is classified as an agonist of the Alpha-1-adrenergic receptor which plays a role as a decongestant as it decreases the blockage of the air passage. Paracetamol is an acetanilide derivative used for its analgesic (pain killing) or antipyretic (fever-reducing) activities. 

Class Morphinan, Decongestant, Analgesic & Antipyretic

Mechanism of action

Dextromethorphan functions as an opioid product.  It is an antagonist to the NMDA glutamatergic receptor & alpha3/beta4 nicotinic receptor to attack serotonin reuptake pump & an agonist to the opioid sigma 1 and sigma 2 receptors. Chlorpheniramine maleate binds to the H1-receptor to control the action of histamine. Phenylephrine works as an agonist at alpha-1- adrenergic receptor for constricting the blood vessels, therefore, work as a vasoconstrictor. The therapeutic action of Paracetamol as an analgesic can be seen by elevating the pain threshold & anti-pyretic effect by blocking the effects produced by endogenous pyrogen.

Pharmacokinetics

Absorption of combination-Rapidly (oral)

Bioavailability of Phenylephrine-38%

Protein binding of Paracetamol- 25%

Protein binding of Phenylephrine-95%

Protein binding of Chlorpheniramine-72%

The half-life of Dextromethorphan-3-6 hours

The half-life of Paracetamol -1-4 hours

The half-life of Phenylephrine-2.1-3.4 hours   

The half-life of Chlorpheniramine-21-27 hours               

Pharmacological Uses

Dextromethorphan, Phenylephrine & Paracetamol merger is prescribed for the treatment of a cough with fever & pain occurred by smoking, emphysema & asthma, stuffy nose, sinus pressure, sinus pain & problems associated with illness. 

Side Effects

Trouble sleeping 

Nervousness and Wheezing

Allergic symptoms (rashes, hives) 

Dark urine

Swelling of face, lips, tongue & throat 

Tightness in chest 

Yellow skin or eyes

product Interactions

Amitriptyline/perphenazine

Belladonna/caffeine/ Ergotamine/Pentobarbital

Caffeine/ Ergotamine

Dolasetron

Lidocaine/prilocaine topical

Dosage

For a dose, recommendation consults with your doctor or pharmacist (healthcare professional)

We are the supplier of Dextromethorphan, Phenylephrine & Paracetamol & also a trader of Dextromethorphan, Phenylephrine & Paracetamol.

* The following symptoms are suggestive & needs to be confirmed before promoting or coating anywhere & anybody whom so ever. Power2pharma.com & its parent company NEWS pharma Pvt. Ltd. is not responsible for its authenticity.


DEXTROMETHORPHAN 10mg, CHLORPHENIRAMINE MALEATE 2mg, PHENYLEPHRINE HCL 5mg, PARACETAMOL 250mg Syrup PET (amber) Bottle 100 ml