PHARMA THIRD PARTY CONTRACT MANUFACTURER OF AMLODIPINE & ATORVASTATIN
Amlodipine besylate belongs to the family of calcium channel blocker for lowering the blood pressure in hypertension. They work to lessen the workload (pump) of Heart by relaxing the blood vessels. Atorvastatin calcium is an HMG CoA reeducates inhibitors that are the family of statins. It is used for lowering the bad-cholesterol level & raising good- cholesterol level in the body.
Class Calcium channel blocker & Statins
Mechanism of action
Amlodipine works on the principle of blocking the calcium ion influx across the cell membrane due to which vasodilatation occurs & peripheral vascular resistance decreases to lower the blood pressure whereas Atorvastatin action for lowering bad cholesterol is shown by inhibiting HMG CoA reductase enzyme which is essential for the reduction conversion of HMG CoA to mevalonate thereby inhibit bad cholesterol synthesis.
Absorption- Amlodipine Slowly but completely absorbed from GIT.
Bioavailability of Amlodipine-64-90%
Bioavailability of Atorvastatin-14%
Protein binding of Amlodipine-97.5%
Protein binding of Atorvastatin-98%
The half-life of Amlodipine-30-50 hours
The half-life of Atorvastatin-14 hours, HMG CoA inhibitors-20-30 hours.
Amlodipine & Atorvastatin can be prescribed for the management of High blood pressure to prevent heart attack, kidney, strokes, Angina Pectoris (Coronary Artery Disease), Coronary artery disease & For raising good cholesterol thereby decrease the risk of heart problems & also for chronic stable angina pectoris.
Swelling of hands/ankle/feet
Tiredness & Weakness
This combination is contraindicated in pregnancy & can be used for a patient of a minimum 10 years of age.
Almasilate, Aluminum (serum concentration of Atorvastatin decreases)
Amiodarone (decreases metabolism of Atorvastatin)
Barbexaclone, Barbital (Increases metabolism of Amlodipine)
For a dose, recommendation consults with your doctor or pharmacist (healthcare professional).
We are the supplier of Amlodipine & Atorvastatin & also a trader of Amlodipine & Atorvastatin.
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