General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF ACECLOFENAC, PARACETAMOL & CHLORZOXAZONE

Introduction


Aceclofenac & Paracetamol is a non-steroidal anti-inflammatory product (NSAIDs) & Chlorzoxazone is a centrally acting muscle-relaxant. This combination main function is to remove muscle pain, body pain& fever from the body. It helps in relieving pain & inflammation. Chlorzoxazone acts on the spinal cord by depressing reflex so that block nerve impulses (or pain sensation) chlorzoxazone may act by inhibiting calcium influx. 

Class-NSAID, Analgesic, Antipyretic & Skeletal muscle relaxants

Pharmacokinetics 

Rapidly & completely absorbed after oral administration. 

The onset of Action for Paracetamol-30 - 60 minutes

The onset of Action for a Chlorzoxazone-1 hour

Bioavailability of Aceclofenac-100%

Bioavailability of Paracetamol-60-70%

Protein binding of Paracetamol-25% 

Protein binding of Aceclofenac -99%

The half-life of Paracetamol-1-4 hours

The half-life of Aceclofenac -4 hours

Excretion -Urinary excretion 

Mechanism of action 

Aceclofenac inhibits the cyclooxygenase which is responsible for the prostaglandin synthesis. As the prostaglandin (PG’s) level is decreased result in the decreased inflammation & pain at wound point.

Paracetamol is also an obstacle for cyclooxygenase but is weak as compared to other cyclooxygenase inhibitors so it is a weak inhibitor of PG’s.

Chlorzoxazone works as an obstacle for the nerve impulses that transmit signals to the brain.

Pharmacological uses of Aceclofenac, Paracetamol & chlorzoxazone – 

This combination can be indicated or prescribed to reduce pain & inflammation, muscle-relaxant, low back pain, cervical pain, post-traumatic pain, spondylitis. It can be used to treat Rheumatoid arthritis.

Side Effects The adverse effects of Aceclofenac, Paracetamol & chlorzoxazone are 

Heartburn, nausea,

Drowsiness, dizziness

Excitement, restlessness & irritability, 

Jaundice & diarrhea

A headache, abdominal pain, flatulence

Lightheadedness & dyspepsias

Gastrointestinal bleeding & coagulation disorder 

Contraindication It is contraindicated during pregnancy & breastfeeding.

product interaction 

Aceclofenac may increase the plasma concentration of lithium & digoxin, 

Chlorzoxazone is with other CNS depressants causes’ additive CNS depression. 

Dosage- Adults: 1 tablet to be taken 1-3 times a day after meals or as recommended by tour Doctor or Pharmacist.

We are the supplier of ACECLOFENAC 100MG + PARACETAMOL 325MG + CHLORZOXAZONE 250mg & also a trader of ACECLOFENAC 100MG + PARACETAMOL 325MG + CHLORZOXAZONE 250mg.

* The following symptoms are suggestive & needs to be confirmed before promoting or coating anywhere & anybody whom so ever. Power2pharma.com & its parent company NEWS pharma Pvt. Ltd. is not responsible for its authenticity.





 


CHLORZOXAZONE 250mg, PARACETAMOL 325mg, ACECLOFENAC 100mg Tablet ALU-ALU 10*10