PHARMA THIRD PARTY CONTRACT MANUFACTURER OF ACECLOFENAC, PARACETAMOL & CHLORZOXAZONE
Aceclofenac & Paracetamol is a non-steroidal anti-inflammatory product (NSAIDs) & Chlorzoxazone is a centrally acting muscle-relaxant. This combination main function is to remove muscle pain, body pain& fever from the body. It helps in relieving pain & inflammation. Chlorzoxazone acts on the spinal cord by depressing reflex so that block nerve impulses (or pain sensation) chlorzoxazone may act by inhibiting calcium influx.
Class-NSAID, Analgesic, Antipyretic & Skeletal muscle relaxants
Rapidly & completely absorbed after oral administration.
The onset of Action for Paracetamol-30 - 60 minutes
The onset of Action for a Chlorzoxazone-1 hour
Bioavailability of Aceclofenac-100%
Bioavailability of Paracetamol-60-70%
Protein binding of Paracetamol-25%
Protein binding of Aceclofenac -99%
The half-life of Paracetamol-1-4 hours
The half-life of Aceclofenac -4 hours
Excretion -Urinary excretion
Mechanism of action
Aceclofenac inhibits the cyclooxygenase which is responsible for the prostaglandin synthesis. As the prostaglandin (PG’s) level is decreased result in the decreased inflammation & pain at wound point.
Paracetamol is also an obstacle for cyclooxygenase but is weak as compared to other cyclooxygenase inhibitors so it is a weak inhibitor of PG’s.
Chlorzoxazone works as an obstacle for the nerve impulses that transmit signals to the brain.
Pharmacological uses of Aceclofenac, Paracetamol & chlorzoxazone –
This combination can be indicated or prescribed to reduce pain & inflammation, muscle-relaxant, low back pain, cervical pain, post-traumatic pain, spondylitis. It can be used to treat Rheumatoid arthritis.
Side Effects The adverse effects of Aceclofenac, Paracetamol & chlorzoxazone are
Excitement, restlessness & irritability,
Jaundice & diarrhea
A headache, abdominal pain, flatulence
Lightheadedness & dyspepsias
Gastrointestinal bleeding & coagulation disorder
Contraindication It is contraindicated during pregnancy & breastfeeding.
Aceclofenac may increase the plasma concentration of lithium & digoxin,
Chlorzoxazone is with other CNS depressants causes’ additive CNS depression.
Dosage- Adults: 1 tablet to be taken 1-3 times a day after meals or as recommended by tour Doctor or Pharmacist.
We are the supplier of ACECLOFENAC 100MG + PARACETAMOL 325MG + CHLORZOXAZONE 250mg & also a trader of ACECLOFENAC 100MG + PARACETAMOL 325MG + CHLORZOXAZONE 250mg.
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